Adjuvant-active aqueous extracts from Artemisia rupestris L. improve immune responses through TLR4 signaling pathway

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• 作者：Ailian Zhang^a ; ¹ ; ^{xjzal@163.com} ; Yu Yang^a ; Yan Wang^b ; ¹ ; Gan Zhao^c ; Xiumei Yang^a ; Danyang Wang^a ; Bin Wang^c
• 关键词：Aqueous extract ; Artemisia rupestris L. ; Adjuvant effect ; Dendritic cells ; TLR4
• 刊名：Vaccine
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：35
• 期：7
• 页码：1037-1045
• 全文大小：599 K
• 卷排序：35

文摘

AEAR as a novel adjuvant can enhance antigen specific immune response without obvious side effect. AEAR can be used for human and animal vaccines with a minimum of undesirable adverse effect. The enhanced adjuvant effect is mediated by promoting DC maturation via TLR4 signaling pathway.