Silencing HS6ST3 inhibits growth and progression of breast cancer cells through suppressing IGF1R and inducing XAF1

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• 作者：Omid Iravani ; ^{antoi@nus.edu.sg} ; Boon-Huat Bay ; George Wai-Cheong Yip ; ^{georgeyip@nus.edu.sg}
• 关键词：Heparan sulfate ; Gene silencing ; Breast cancer ; Cell growth ; Tumor progression
• 刊名：Experimental Cell Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：350
• 期：2
• 页码：380-389
• 全文大小：1633 K
• 卷排序：350

文摘

HS6ST3 was found up-regulated in T47D, MCF7 and MDA-MB231 breast cancer cell lines. Silencing HS6ST3 diminished tumor cell growth and progression in breast cancer cells. Silencing HS6ST3 down-regulated IGF1R and up-regulated XAF1 in breast cancer cells. Co-targeting IGF1R and XAF1 could reduce the breast cancer growth and progression. Targeting HS6ST3 could be useful in breast cancer therapy.