HIV and Tfh Cells: Circulating New Ideas to Identify and Protect

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• 作者：Ann Chahroudi¹ ; ³ ; Guido Silvestri² ; ³ ; ⁴ ; ^{gsilves@emory.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Immunity
• 出版年：2016
• 出版时间：19 January 2016
• 年：2016
• 卷：44
• 期：1
• 页码：16-18
• 全文大小：347 K

文摘

T follicular helper (Tfh) cells provide crucial support to antigen-specific B cells. In this issue of Immunity, Schultz et al. (2016) report that circulating IL-21-producing CD4⁺ T cells are phenotypically, transcriptionally, and functionally similar to lymphoid Tfh cells and that such HIV-specific Tfh cells were increased in RV144 trial vaccine recipients.