Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific
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- 作者：Lisa H. Tostanoski1 ; Yu-Chieh Chiu1 ; Joshua M. Gammon1 ; Thomas Simon2 ; 3 ; James I. Andorko1 ; Jonathan S. Bromberg2 ; 3 ; 4 ; 5 ; Christopher M. Jewell1 ; 4 ; 5 ; 6 ; 7 ; cmjewell@umd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：lymph node ; immune tolerance ; biomaterial ; autoimmunity ; microparticle ; regulatory T cell ; vaccine ; nanoparticle ; CNS ; multiple sclerosis
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：13 September 2016
- 年：2016
- 卷：16
- 期：11
- 页码：2940-2952
- 全文大小：5315 K
文摘
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A single intra-lymph node (i.LN.) particle dose reverses autoimmunity/paralysis in mice
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Efficacy is dependent on delivery of encapsulated self-antigen to lymph nodes (LNs)
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i.LN. delivery of particles reprograms local LN cell composition and function
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Altered local function in LNs promotes systemic but antigen-specific tolerance