Effects of montelukast on the healing of ischemic colon anastomoses

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• 作者：Atilla Celik ; Ersin Ergun ; Neset Koksal ; Aysun Simsek Celik ; Ediz Altinli ; Mehmet Ali Uzun ; Ersan Eroglu ; Ahu Kemik
• 关键词：Ischemia/reperfusion ; Colon anastomoses ; Montelukast
• 刊名：The American Journal of Surgery
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：206
• 期：4
• 页码：502-508
• 全文大小：168 K

文摘

Background

The aim of this study was to examine whether treatment with montelukast, a selective leukotriene antagonist, would affect anastomotic healing in a reperfused colon rat model with remote ischemia/reperfusion injury.

Methods

Rats (n = 12 per group) were intraperitoneally administered normal saline or 10 mg/kg montelukast sodium 60 minutes before and for 5 days after surgery. Ischemia was induced for 45 minutes through superior mesenteric artery occlusion. A left colon anastomosis was made. Blood and perianastomotic tissue samples were obtained on postoperative day 5.

Results

Mean anastomotic bursting pressures of the control and montelukast groups were 159.17 ¡À 29.99 and 216.67 ¡À 26.40, respectively (P < .001). Compared with saline, montelukast treatment increased the mean tissue hydroxyproline level (2.46 ¡À .30 vs 3.61 ¡À .33 ¦Ìmol/L) and decreased tissue caspase-3 activity (36.06 ¡À 5.72 vs 21.78 ¡À 3.87) and malondialdehyde levels (3.43 ¡À .34 vs 2.29 ¡À .34 nmol/g) (P < .001 for all). Other plasma markers of injury also showed differences.

Conclusions

Montelukast prevented ischemia/reperfusion-induced damage in a rat model of colonic?anastomotic wound healing.