Designing artificial enzymes from scratch: Experimental study and mesoscale simulation
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- 作者：Pavel V. Komarova ; b ; pv_komarov@mail.ru" class="auth_mail" title="E-mail the corresponding author ; Olga E. Zaborinaa ; Tamara P. Klimovaa ; Vladimir I. Lozinskya ; Pavel G. Khalatura ; c ; Alexey R. Khokhlova ; d
- 关键词：Biomimetic molecular systems ; Bioinspired nanocatalyst ; Protein-like copolymers ; Radical copolymerization ; Computer-aided design ; Mesoscale simulations
- 刊名：Chemical Physics Letters
- 出版年：2016
- 出版时间：16 September 2016
- 年：2016
- 卷：661
- 期：Complete
- 页码：219-223
- 全文大小：1333 K
文摘
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A new concept for designing of biomimetic analogs of enzymatic proteins was proposed.
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α-Chymotrypsin was used as a prototype of the artificial catalyst.
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The target globular nanostructures of a “core-shell” morphology were synthesized.
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Our simulation showed that such globules can have a big number of catalytic centers.