Synthesis and bio-evaluation of xylan-5-fluorouracil-1-acetic acid conjugates as prodrugs for colon cancer treatment

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• 作者：Sauraj^a ; S. Uday Kumar^b ; P. Gopinath^b ; ^c ; Yuvraj Singh Negi^a ; ^{yuvrajnegi@gmail.com}
• 关键词：Xylan ; 5-Fluorouracil-1-acetic acid (5-FUAC) ; Drug release ; Gastrointestinal contents ; Cell cytotoxicity
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：1442-1450
• 全文大小：2209 K
• 卷排序：157

文摘

Xyl-5-FUAC conjugates were synthesized as prodrugs for colon specific drug delivery. Higher amount of drug was released from the conjugates in presence of colonic contents. Xyl-5-FUAC conjugates shows better cytotoxicity than free drug.