Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses
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- 作者：Britney Johnson1 ; &dagger ; ; Jing Li2 ; &dagger ; ; Jagat Adhikari2 ; Megan R. Edwards1 ; 3 ; Hao Zhang2 ; Toni Schwarz4 ; Daisy W. Leung1 ; Christopher F. Basler3 ; 4 ; Michael L. Gross2 ; mgross@wustl.edu" class="auth_mail" title="E-mail the corresponding author ; Gaya K. Amarasinghe1 ; gamarasinghe@path.wustl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Marburg virus ; VP24 ; antioxidative stress ; viral subversion ; hydrogen deuterium exchange mass spectrometry
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：28 August 2016
- 年：2016
- 卷：428
- 期：17
- 页码：3483-3494
- 全文大小：1376 K
文摘
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Antioxidative response mechanisms modulated by viruses are not well understood.
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Marburg virus VP24 protein oligomerization modulates antioxidative responses.
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Combined biophysical and cell biology study defines a novel mechanism.
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Conformational changes provides a novel target for antiviral development.