Decreased mRNA expression for the two subunits of system xc−, SLC3A2 and SLC7A11, in WBC in patients with schizophrenia: Evidence in support of the hypo-glutamatergic hypothesis of schizophrenia
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- 作者：Chieh-Hsin Lina ; b ; Pei-Pei Linb ; Chun-Yuan Linc ; Ching-Hua Lind ; Chiung-Hsien Huange ; Yu-Jhen Huange ; Hsien-Yuan Laneb ; e ; hylane@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：System xc&minus ; SLC3A2 ; SLC7A11 ; glutamate ; Schizophrenia
- 刊名：Journal of Psychiatric Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：72
- 期：Complete
- 页码：58-63
- 全文大小：409 K
文摘
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The cystine/glutamate antiporter system xc−, playing a critical role in the regulation of glutamate release, might be implicated in the pathogenesis of schizophrenia.
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This is the first study indicating that the peripheral gene expression levels of the two system xc- subunits, SLC3A2 and SLC7A11, may be lower in patients with schizophrenia than healthy individuals.
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The finding supports the hypo-glutamatergic neurotransmission hypothesis in schizophrenia.