MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11

详细信息    查看全文

• 作者：Xiao-Xiao Liu^a ; ¹ ; Xiao-Jun Li^a ; ¹ ; Bo Zhang^b ; Yong-Jun Liang^a ; Ci-Xiang Zhou^a ; Dan-Xia Cao^c ; Ming He^d ; Guo-Qiang Chen^d ; Jian-Rong He^c ; ^{HEJRONG@hotmail.com"" rel=""nofollow} ; Qian Zhao^a ; ^d ; ^{qzhao@shsmu.edu.cn"" rel=""nofollow}
• 关键词：miR-26b ; SLC7A11 ; Apoptosis ; Breast cancer
• 刊名：FEBS Letters
• 出版年：2011
• 出版时间：6 May 2011
• 年：2011
• 卷：585
• 期：9
• 页码：1363-1367
• 全文大小：782 K

文摘

MicroRNAs are widely dysregulated in various cancers and integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. Here, we show that miR-26b, which is down-regulated in human breast cancer specimens and cell lines, impairs viability and triggers apoptosis of human breast cancer MCF7 cells. SLC7A11 is identified as a direct target of miR-26b and its expression is remarkably increased in both breast cancer cell lines and clinical samples. Furthermore, SLC7A11 silence mimics miR-26b-aroused viability impairment and apoptosis in MCF7 cells. Our studies reveal a protective role of miR-26b in the molecular etiology of human breast cancer by promoting apoptosis.