刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:645-650
全文大小:742 K
卷排序:482
文摘
Airway cells with lower SMPD1 activity increases neutrophil chemotaxis towards them. Decreasing SMPD1 activity in epithelial cells leads to higher cytokine secretion. Decreasing SMPD1 activity results in a pro-oxidative shift of epithelial cells. An inactive SMPD1 mutant activates NRF2 in airway epithelial cells.