Associated degeneration of ventral tegmental area dopaminergic neurons in the rat nigrostriatal lactacystin model of parkinsonism and their neuroprotection by valproate
详细信息 查看全文
- 作者：Ian F. Harrisona ; b ; ian.harrison@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Hiba K. Anisb ; David T. Dexterb
- 关键词：PD ; Parkinson&rsquo ; s disease ; SNpc ; Substantia Nigra pars compacta ; αSyn ; α-synuclein ; VTA ; ventral tegmental area ; UPS ; ubiquitin proteasome systems ; HAT ; histone acetyltransferase ; HDAC ; histone deacetylase ; HDACI ; histone deacetylase inhibitor ; TH ; tyrosine hydroxylase
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：12 February 2016
- 年：2016
- 卷：614
- 期：Complete
- 页码：16-23
- 全文大小：2011 K
文摘
- •
Intranigral lactacystin causes degeneration of adjacent VTA dopaminergic neurons.
- •
Valproate is protective to VTA neurons in the lactacystin rat model of Parkinson’s.
- •
Valproate is a candidate for extra-nigral as well as intra-nigral neuroprotection.