Neuroprotection by caffeine in the MPTP model of parkinson’s disease and its dependence on adenosine A2A receptors
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- 作者：K. Xua ; kuixu@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; D.G. Di Lucaa ; dilucadaniel@gmail.com" class="auth_mail" title="E-mail the corresponding author ; M. Orrú ; a ; orrumarco@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Y. Xua ; xuy@helix.mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; J.-F. Chenb ; chenjf@bu.edu" class="auth_mail" title="E-mail the corresponding author ; M.A. Schwarzschilda ; michaels@helix.mgh.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：6-OHDA ; 6-hydroxydopamine ; MPTP ; 1-methyl-4-phenyl-1 ; 2 ; 3 ; 6 tetra-hydropyridine ; PD ; parkinson&rsquo ; s disease ; SNpc ; substantia nigra pars compacta ; WT ; wild-type
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：322
- 期：Complete
- 页码：129-137
- 全文大小：562 K
文摘
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Neuroprotection by caffeine requires the adenosine A2AR.
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Neuroprotection by caffeine depends in part on A2ARs other than those on forebrain neurons.
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Caffeine’s locomotor activating properties are dependent upon forebrain A2ARs.
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Caffeine does not require astrocyte A2ARs to protect dopaminergic neurons.