Suppressor of cytokine signaling 2 modulates the immune response profile and development of experimental cerebral malaria
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- 作者：Fatima Branta ; b ; 1 ; Aline S. Mirandaa ; b ; 1 ; Lisia Espera ; b ; Melisa Gualdró ; n-Ló ; pezb ; Daniel Cisalpinoc ; Danielle da Gloria de Souzac ; Milene Alvarenga Rachidd ; Herbert B. Tanowitze ; Mauro Martins Teixeiraa ; b ; Antô ; nio Lucio Teixeiraa ; b ; Fabiana Simã ; o Machadoa ; b ; machadofs@icb.ufmg.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：SOCS2 ; Cerebral malaria ; Immune regulation ; Neuroinflammation ; Neurotrophic factors ; Neuroimmune response ; BDNF ; GDNF ; l-NAME ; Nitric oxide
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：73-85
- 全文大小：2596 K
文摘
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Plasmodium berghei ANKA (PbA) infection decreases SOCS2 expression in brain.
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SOCS2 orchestrates immune response and neuroinflammation during PbA infection.
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Neurotrophic factors production is modulated by SOCS2.
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SOCS2 control anxiety-related behaviour and cognitive decline during PbA infection.
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Interrelation of SOCS2/NO in the orquestration of immune response and CM outcome.