Direct C2-trifluoromethylation of indole derivatives catalyzed by copper acetate

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• 作者：Ryo Shimizu ; Hiromichi Egami ; Tatsuya Nagi ; Jungha Chae ; Yoshitaka Hamashima ; Mikiko Sodeoka
• 关键词：Trifluoromethylation ; Indole ; Catalysis ; Regioselective
• 刊名：Tetrahedron Letters
• 出版年：2010
• 出版时间：10 November 2010
• 年：2010
• 卷：51
• 期：45
• 页码：5947-5949
• 全文大小：305 K

文摘

Direct C2-selective trifluoromethylation of indole derivatives was achieved with Togni’s hypervalent iodine reagent and CuOAc as a catalyst in MeOH under mild conditions, affording the desired C2-trifluoromethylated indoles in good yield (up to 90 % ).