Natriuretic peptides in addition to Zwolle score to enhance safe and early discharge after acute myocardial infarction: A prospective observational cohort study

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• 作者：Eva Ganovska^a ; ^b ; ¹ ; ^{evaganovska@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mattia Arrigo^c ; ^d ; ^e ; ^k ; ¹ ; ^{mattia.arrigo@usz.ch" class="auth_mail" title="E-mail the corresponding author} ; Katerina Helanova^a ; ^b ; ^{trekar@seznam.cz" class="auth_mail" title="E-mail the corresponding author} ; Simona Littnerova^f ; ^{littnerova@iba.muni.cz" class="auth_mail" title="E-mail the corresponding author} ; Malha Sadoune^a ; ^{malha.sadoune@inserm.fr" class="auth_mail" title="E-mail the corresponding author} ; Petr Kubena^a ; ^b ; ^{petrkubena@seznam.cz" class="auth_mail" title="E-mail the corresponding author} ; Marie Pavlusova^a ; ^b ; ^{mpavlusova@seznam.cz" class="auth_mail" title="E-mail the corresponding author} ; Jiri Jarkovsky^f ; ^{jarkovsky@iba.muni.cz" class="auth_mail" title="E-mail the corresponding author} ; Jana Gottwaldova^g ; ^h ; ^{jgottwaldova@fnbrno.cz" class="auth_mail" title="E-mail the corresponding author} ; Petr Kala^a ; ^b ; ^{pkala@fnbrno.cz" class="auth_mail" title="E-mail the corresponding author} ; Milan Dastych^g ; ^h ; ^{mdast@fnbrno.cz" class="auth_mail" title="E-mail the corresponding author} ; Shiro Ishihara^a ; ^{ishiharashiro@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Lucas N.L. Van Aelst^c ; ^e ; ⁱ ; ^{lucas.vanaelst@med.kuleuven.be" class="auth_mail" title="E-mail the corresponding author} ; Alain Cohen-Solal^c ; ^e ; ^j ; ^{alain.cohen-solal@aphp.fr" class="auth_mail" title="E-mail the corresponding author} ; Etienne Gayat^c ; ^d ; ^j ; ^{etienne.gayat@aphp.fr" class="auth_mail" title="E-mail the corresponding author} ; Jindrich Spinar^a ; ^b ; ^{jspinar@fnbrno.cz" class="auth_mail" title="E-mail the corresponding author} ; Jiri Parenica^a ; ^b ; ^{jiri.parenica@atlas.cz" class="auth_mail" title="E-mail the corresponding author} ; Alexandre Mebazaa^c ; ^d ; ^j ; ^{alexandre.mebazaa@aphp.fr" class="auth_mail" title="E-mail the corresponding author} ; on behalf of the GREAT Network
• 关键词：Myocardial infarction ; STEMI ; Discharge ; Zwolle ; BNP
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 July 2016
• 年：2016
• 卷：215
• 期：Complete
• 页码：527-531
• 全文大小：447 K

文摘

The Zwolle score is recommended to identify low-risk patients eligible for early hospital discharge after ST-elevation myocardial infarction (STEMI), but since only one third of STEMI has low Zwolle score, hospital discharge is frequently delayed. B-type natriuretic peptide (BNP) also provides prognostic information after STEMI. The aim of the study was to test the hypothesis that patients with high Zwolle score associated with low BNP share similar outcomes than those with low Zwolle score.

Methods and results

The study population consisted of 1032 consecutive STEMI patients in whom BNP was measured 24 h after chest pain onset. The area under the curve of Zwolle score and plasma BNP for 30-day mortality were 0.82 and 0.87, p = 0.39. A BNP threshold of 200 pg/ml had sensitivity of 100% and specificity of 34% for predicting 30-day mortality. Patients with high Zwolle score and BNP ≤ 200 pg/ml (n = 183) had similar mortality and hospital stay to those with low Zwolle score (0% vs. 0.5% and 5 vs. 5 days, both p = 1.0). By contrast, patients with high Zwolle score and BNP > 200 pg/ml had the highest mortality (6.7%) and the longest hospital stay (6 days), both p < 0.01.

Conclusion

STEMI patients with high Zwolle score but low BNP share similar outcomes with those with low Zwolle score and should be eligible for early discharge. Hence, using the rule of “low-Zwolle or low-BNP” might increase the number of STEMI patients that might be eligible for early discharge.