Alpha synuclein dimers and oligomers are increased in overexpressing conditions in vitro and in vivo
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- 作者：D. Marmolinoa ; daniele.marmolino@ucb.com" class="auth_mail" title="E-mail the corresponding author ; P. Foerchb ; F.A. Atienzarc ; L. Staelensa ; A. Michela ; D. Schellera
- 关键词：Alpha synuclein ; Parkinson's disease ; Toxicity
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：71
- 期：Complete
- 页码：92-101
- 全文大小：1004 K
文摘
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WT ASYN and PD-linked mutation exhibit different cytotoxicity profiles.
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PD-linked point mutations severely impact cellular viability compared to WT ASYN.
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Dimers/oligomers amount is increased under overexpressing conditions.
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Deregulation in the oligomerization process could be responsible for the toxic events.