Hydrogen sulfide depolarizes neurons in the nucleus of the solitary tract of the rat
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- 作者：Rishi Malik ; Alastair V. Ferguson ; avf@queensu.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hydrogen sulfide ; Nucleus tractus solitaries ; Patch clamp ; KATP channels
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：1633
- 期：Complete
- 页码：1-9
- 全文大小：1591 K
文摘
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We report of direct H2S effects on membrane potential of NTS neurons.
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H2S has reversible, depolarizing effects on 95% of NTS neurons tested (72/76).
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These effects were postsynaptic (observed in tetrodotoxin and kynurenic acid).
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Depolarization was followed by a hyperpolarization in 64% of neurons.
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Hyperpolarizations were the result of the modulation of KATP channels.