Urea derivates of ursolic, oleanolic and maslinic acid induce apoptosis and are selective cytotoxic for several human tumor cell lines
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- 作者：Sven Sommerwerk ; Lucie Heller ; Julia Kuhfs ; René ; Csuk ; rene.csuk@chemie.uni-halle.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ursolic acid ; Oleanolic acid ; Maslinic acid ; Tumor cells ; SRB assay ; Apoptosis
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：119
- 期：Complete
- 页码：1-16
- 全文大小：1682 K
文摘
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Urea derivatives of ursolic, oleanolic and maslinic acid were synthesized.
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They were tested for their antitumor activity using human cancer cell lines.
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A (2β,3β)-diacetoxy moiety in an oleanane skeleton increases cytotoxicity.
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The compounds are cytostatic and act by apoptosis.