Reirradiation of paraaortic lymph node metastasis by brachytherapy with hyaluronate injection via paravertebral approach: With DVH comparison to IMRT

详细信息    查看全文

• 作者：Kazushi Kishi¹ ; ^{kazushi.kishi@gmail.com} ; Tetsuo Sonomura¹ ; Shintaro Shirai¹ ; Yasutaka Noda¹ ; Morio Sato¹ ; Hitoshi Ikushima² ; Ryoong-Jin Oh³
• 关键词：Reirradiation ; Paraaortic lymph node ; High-dose-rate brachytherapy ; Hyaluronate ; Risk organ ; Prostate cancer ; Bowel
• 刊名：Brachytherapy
• 出版年：2013
• 出版时间：January-February, 2013
• 年：2013
• 卷：12
• 期：1
• 页码：8-13
• 全文大小：840 K

文摘

Purpose/Introduction

To safely irradiate retroperitoneal targets as paraaortic lymph node by separating abdominal at-risk organs from the target during irradiation, we created a percutaneous paravertebral approach of high-dose-rate brachytherapy with hyaluronate gel injection (HGI). We report a case treated with this technique.

Methods and Materials

We encountered a patient with symptomatic regrowth of paraaortic lymph node metastasis from prostatic cancer. He had previously received 58.4 Gy of radiotherapy to the same region 12 months prior. Brachytherapy needles and a HGI needle were deployed via the paravertebral approach under local anesthesia at our outpatient clinic.

Results

A single dose of 22.5 Gy (equivalent to 60.94 Gy in 2 Gy per fraction schedule calculated at ¦Á/¦Â = 10) was delivered to the target, with preservation of the surrounding small intestine by HGI with D_2cc (minimum dose to the most irradiated volume of 2 mL) of 5.05 Gy. Therapeutic ratio was 3.64 times higher for this brachytherapy plan compared with an intensity-modulated radiation therapy plan. At followup at 1 year after brachytherapy, the symptoms had disappeared, tumor size had reduced with no fluorodeoxyglucose accumulation, and prostate-specific antigen level had decreased.

Conclusion

We consider that high-dose-rate brachytherapy with the HGI procedure offers effective treatment even in this type of reirradiation situation.