The protective effect of neutralizing high-mobility group box1 against chronic cyclosporine nephrotoxicity in mice
详细信息 查看全文
- 作者：Hoon Suk Park ; Eun Nim Kim ; Min Young Kim ; Ji Hee Lim ; Hyung Wook Kim ; Cheol Whee Park ; Chul Woo Yang ; Dong Chan Jin ; Bum Soon Choi ; sooncb@catholic.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CsA ; cyclosporine ; CNI ; calcineurin inhibitor ; DAMP ; damage-associated molecular pattern molecule ; HMGB1 ; high-mobility group box1 ; IRI ; ischemia-reperfusion injury ; NF-κB ; nuclear factor kappa B ; PAMP ; pathogen-associated molecule pattern molecule ; RAGE ; receptor for advanced glycation end products ; TLR ; toll-like receptor
- 刊名：Transplant Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：34
- 期：Complete
- 页码：42-49
- 全文大小：1441 K
文摘
- •
Chronic CsA nephrotoxicity is the major cause of chronic renal allograft dysfunction.
- •
Chronic CsA nephrotoxicity is mediated by immunologic and non-immunologic pathways.
- •
HMGB1 is an important mediator in chronic CsA nephrotoxicity via TLR4 signaling.
- •
HMGB1 blockade protects against chronic CsA nephrotoxicity.
- •
HMGB1 blockade can be beneficial for increasing renal allograft survival.