Nanomechanical signatures of oral submucous fibrosis in sub-epithelial connective tissue

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• 作者：Anji Anura^a ; ^{anji.anura7@gmail.com} ; Debanjan Das^b ; Mousumi Pal^c ; Ranjan Rashmi Paul^c ; Soumen Das^a ; Jyotirmoy Chatterjee^a
• 关键词：Atomic force microscopy (AFM) ; Oral submucous fibrosis (OSF) ; Nanomechanical properties ; Extracellular matrix ; Collagen ; Young's modulus
• 刊名：Journal of the Mechanical Behavior of Biomedical Materials
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：65
• 期：Complete
• 页码：705-715
• 全文大小：2376 K
• 卷排序：65

文摘

Rearrangement of collagen fibers and their structural alteration in OSF connective tissue. Increase in Young's modulus of ECM in OSF as compare to normal oral mucosa. Enhanced adhesion force and diminished deformation property with development of OSF. α-SMA positive fibroblast in OSF subepithelium suggests excessive production of ECM. Change in collagen expression correlates with AFM findings in normal and OSF tissue.