Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,N′-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines
Hydrophobic and hydrophilic benzimidazolium salts were synthesized/characterized. Benzimidazolium salts were tested for their anti-cancer properties. Lipophilic benzimidazolium salts have higher anti-cancer activity. NCI’s DTP tested 21 compounds in the NCI-60 human tumor cell line screen.