Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence
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- 作者：Olga Spadaro1 ; Emily L. Goldberg1 ; Christina D. Camell1 ; Yun-Hee Youm1 ; John J. Kopchick2 ; Kim Y. Nguyen1 ; Andrzej Bartke3 ; Liou Y. Sun4 ; Vishwa Deep Dixit1 ; 5 ; vishwa.dixit@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：23 February 2016
- 年：2016
- 卷：14
- 期：7
- 页码：1571-1580
- 全文大小：3832 K
文摘
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The long-lived GH-R-deficient mice are protected from inflammaging
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Loss of GH-R deactivates NLRP3 inflammasome and increases naive T cells in aging
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Ablation of macrophage IGF1-IGF1R axis inhibits the inflammasome
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Macrophage somatotrophic axis regulates NLRP3 inflammasome in aging