Beneficial metabolic actions of a stable GIP agonist following pre-treatment with a SGLT2 inhibitor in high fat fed diabetic mice
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- 作者：P.J.B. Millara ; V. Pathaka ; R.C. Moffetta ; N.M. Pathaka ; A.J. Bjoursonb ; M.J. O'Kaneb ; c ; P.R. Flatta ; V.A. Gaulta ; va.gault@ulster.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dapagliflozin ; Diabetes ; Glucose-dependent insulinotropic polypeptide (GIP) ; Insulin secretion ; SGLT2 inhibitor
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：420
- 期：Complete
- 页码：37-45
- 全文大小：1417 K
文摘
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(dAla2)GIP improved glucose tolerance, insulin secretion/sensitivity following DAPA pre-treatment.
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(dAla2)GIP reversed DAPA-induced increase in alpha cell area.
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DAPA treatment reversed impaired action of (dAla2)GIP under hyperglycaemic conditions.
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Possibility of therapy using a GIP agonist and SGLT2 inhibitor.