Lipid-dependent protein sorting at the trans-Golgi network

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• 作者：Michal A. Surma ; Christian Klose ; Kai Simons ; ^{simons@mpi-cbg.de}
• 关键词：Lipid raft ; Trans-Golgi network ; Sorting ; Cargo ; Golgi apparatus ; Secretory pathway
• 刊名：Biochimica et Biophysica Acta (BBA)/Molecular and Cell Biology of Lipids
• 出版年：2012
• 出版时间：August, 2012
• 年：2012
• 卷：1821
• 期：8
• 页码：1059-1067
• 全文大小：619 K

文摘

In eukaryotic cells, the trans-Golgi network serves as a sorting station for post-Golgi traffic. In addition to coat- and adaptor-mediated mechanisms, studies in mammalian epithelial cells and yeast have provided evidence for lipid-dependent protein sorting as a major delivery mechanism for cargo sorting to the cell surface. The mechanism for lipid-mediated sorting is the generation of raft platforms of sphingolipids, sterols and specific sets of cargo proteins by phase segregation in the TGN. Here, we review the evidence for such lipid-raft-based sorting at the TGN, as well as their involvement in the formation of TGN-to-PM transport carriers. This article is part of a Special Issue entitled Lipids and Vesicular Transport.