Labeled chemical biology tools for investigating sphingolipid metabolism, trafficking and interaction with lipids and proteins
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- 作者：Gü ; nter Schwarzmanna ; schwarzmann@uni-bonn.de" class="auth_mail ; Christoph Arenzb ; christoph.arenz@chemie.hu-berlin.de" class="auth_mail ; Konrad Sandhoffa ; sandhoff@uni-bonn.de" class="auth_mail
- 关键词：2-NBD-GM1 ; 2-(R/S)-nitrobenzodiazol-GM1 ; 2-NBD-GM2 ; 2-(R/S)-nitrobenzodiazol-GM2 ; BMP ; bis(monoacylglycero)phosphate ; BODIPY ; 4 ; 4&prime ; -difluoro-4-bora-(3a ; 4a)-diaza-s-indacene ; CTB ; cholera toxin subunit B ; doxyl ; 4 ; 4-dimethyl-3-oxazolidinyloxy ; free radical ; DPH ; diphenylhexatrienyl ; FRET ; Fö ; rster resonance energy transfer ; GM2AP ; ganglioside GM2 activator protein ; HexA ; 尾-hexosaminidase A ; NBD ; nitrobenzodiazol ; NR ; Nile Red ; Sap ; saposin ; C3-TPD-GM2[14C]C3-TPD-GM2 ; 2-acetamido-2-deoxy-
- 刊名：Biochimica et Biophysica Acta (BBA)/Molecular and Cell Biology of Lipids
- 出版年：August 2014
- 年：2014
- 卷：1841
- 期：8
- 页码：1161-1173
- 全文大小：1485 K
文摘
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Fluorescent sphingolipids are perfect for FRET studies in lipid–protein interaction.
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Biotin-GM1 discloses intracellular localization by immuno-electron microscopy.
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Photoactivatable GM2 labels the binding site of GM2 activator protein.
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Non-degradable glycosphingolipids for metabolic and traffic studies
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Synthetic inhibitors of acid sphingomyelinase