Computational characterization and in vivo expression of squalene synthase gene in different tissues of Artemisia annua L. plants
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- 作者：Athar Alia ; Malik Mobeen Ahmadb ; Mather Ali Khanc ; Ajaz Ahmad Ganaia ; Usha Kirana ; Amresh Prakashd ; Md. Imtiyaz Hassand ; Parul Saxenaa ; Shazia Khana ; Seema Ahlawata ; Malik Zainul Abdina ; mzabdin@jamiahamdard.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Artemisinin ; Gas chromatography&ndash ; Mass spectrometry (GC&ndash ; MS) ; Homology modeling ; Malaria ; Squalene synthase gene and Real-time PCR
- 刊名：South African Journal of Botany
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：169-177
- 全文大小：1645 K
文摘
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Artemisinin is the key ingredient used in the form of ACTs to treat drug resistant malaria.
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SQS catalyzes the first step of sterol biosynthetic pathway that competes with artemisinin biosynthesis for FPP in A. annua L.
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The computational approaches of AaSQS might be helpful in modulating the triterpenoid biosynthesis in A. annua L. plants.