One-pot sequential multicomponent route to 2,4-diaminothiazoles¡ªa facile approach to bioactive agents for cancer therapeutics

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• 作者：Kumaran G. Sreejalekshmi^a ; ^{sreeja@iist.ac.in} ; Kallikat N. Rajasekharan^b
• 关键词：Diaminothiazole ; Synthesis ; One-pot ; Sequential multicomponent ; Nitroguanidine
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：11 July, 2012
• 年：2012
• 卷：53
• 期：28
• 页码：3627-3629
• 全文大小：704 K

文摘

A facile one-pot sequential three-component route to 2,4-diaminothiazoles is reported. The new approach employs the mildest reaction conditions and commercially available reagents to generate diverse 2-alkyl/arylamino-4-amino-5-aroyl/heteroylthiazoles in short reaction times, good yield, and purity.