We describe a systematic procedure for the monitoring and analysis of bottom-hole pressure data during CO2 injection into deep saline aquifers. Our methodology builds upon well injectivity and pressure transient analysis techniques developed in the petroleum industry for fluid injection systems. Using field data from AEP's Mountaineer Plant CO2 geologic sequestration project, we show how late-time pressure falloff response at monitoring wells can be interpreted to estimate intrinsic permeability of the reservoir. Effective total compressibility values estimated from history matching of post-breakthrough injection-falloff sequences at different times can also be utilized for tracking the CO2-brine front.