Outcome and prognostic factors of postoperative radiation therapy (PORT) after incomplete resection of non-small cell lung cancer (NSCLC)
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- 作者：Juliane Riebera ; b ; Alexander Deega ; b ; Elena Ullrichc ; d ; Robert Foerstera ; b ; Marc Bischofe ; Arne Warthf ; Philipp A. Schnabelg ; Thomas Muleyc ; d ; Jutta Kappesc ; h ; Claus Peter Heusselc ; i ; j ; Thomas Welzela ; b ; Michael Thomask ; Martin Steinsk ; Hendrik Dienemannc ; d ; Jü ; rgen Debusa ; b ; Hans Hoffmannc ; d ; Stefan Riekena ; b ; stefan.rieken@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lung cancer ; Non-small cell lung cancer (NSCLC) ; Postoperative radiation therapy (PORT) ; Incompletely resected NSCLC ; Microscopic residual disease
- 刊名：Lung Cancer
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：41-47
- 全文大小：1115 K
文摘
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For incompletely resected NSCLC, PORT is used for improving local tumor control as local progression is still the major pattern of failure.
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Radiation doses >54 Gy seem were associated with significantly improved local control in this retrospective study.
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Furthermore, radiation doses of >54 Gy also significantly prolong distant progression-free survival and overall survival.
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Survival was neither influenced by R1 localization nor by extent of microscopically residual disease (localized vs. diffuse).