Characterization and Risk Factor Analysis of Osteoporosis in a Large Cohort of Patients with Chronic Graft-versus-Host Disease
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- 作者：Filip Pirsl1 ; Lauren M. Curtis1 ; curtislm@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Seth M. Steinberg2 ; Sri Harsha Tella3 ; Ma&scaron ; enjka Katić1 ; Marnie Dobbin4 ; Jennifer Hsu1 ; Fran T. Hakim1 ; Jacqueline W. Mays5 ; Annie P. Im6 ; Dražen Pulanić7 ; 8 ; Sandra A. Mitchell9 ; Judy Baruffaldi1 ; Licia Masuch1 ; David C. Halverson1 ; Ronald E. Gress1 ; Julianna Barsony10 ; Steven Z. Pavletic1
- 关键词：Chronic graft-versus-host disease ; Allogeneic hematopoietic stem cell transplantation ; Osteoporosis ; Late effects ; Supportive care ; Platelets
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：22
- 期：8
- 页码：1517-1524
- 全文大小：453 K
文摘
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The prevalence of osteoporosis and osteopenia in patients with severe chronic graft-versus-host disease (cGVHD) is high.
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A higher platelet count and higher average National Institutes of Health organ score are associated with osteoporosis.
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The femoral neck is the most frequently and most severely affected among the 3 sites studied.
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Our findings suggest a possible independent role of cGVHD in post–allogeneic hemtopoietic stem cell transplantation osteoporosis.