On the chemical modification of pacemaker electrodes and patterned surface functionalization of planar substrates
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- 作者：Stelzle ; Martin ; Wagner ; Roland ; Nisch ; Wilfried ; Jä ; germann ; Wolfram ; Frö ; hlich ; Ronald ; et. al.
- 关键词：chemical surface modification ; pacemaker electrodes ; gas-phase silylation ; monolayer lithography ; cell adhesion ; biocompatibility ; photolithography
- 刊名：Biosensors and Bioelectronics
- 出版年：1997
- 出版时间：1997
- 年：1997
- 卷：12
- 期：8
- 页码：853-865
- 全文大小：1.31 M
文摘
We report on experiments towards the chemical modification of metal electrodes in order to enhance biocompatibility or improve cell adhesion properties. In the first example pacemaker electrodes were modified with a thin polysiloxane network which allowed for further derivatization with a poly(ethylene glycol) layer. The primary goal was to suppress inflammatory response of tissue after implantation of electrodes. FTIR, ESCA and a.c.-impedance spectroscopy show the integrity of the ultrathin membrane. No significant reduction of the electrode capacitance was observed, providing further proof for the deposition of a homogeneously thin membrane.