Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques
Second study to evaluate immunotherapy on drug self-administration in monkeys Vaccination attenuated ongoing cocaine self-administration in 25% of the monkeys. Vaccination retarded reacquisition of cocaine self-administration. The dAdGNE vaccine may have therapeutic potential for relapse prevention.