α-Melanocyte stimulating hormone attenuates dexamethasone-induced osteoblast damages through activating melanocortin receptor 4-SphK1 signaling
详细信息 查看全文
- 作者：Shiguang Guoa ; 1 ; Yue Xieb ; 1 ; Jian-bo Fanc ; 1 ; Feng Jib ; huaiaifengjidr@163.com" class="auth_mail" title="E-mail the corresponding author ; Shouguo Wangb ; Haodong Feib
- 关键词：α-Melanocyte stimulating hormone (α-MSH) ; Dexamethasone ; Osteoblasts ; Melanocortin receptor 4 (MC4R) and sphingosine kinase 1 (SphK1)
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：8 January 2016
- 年：2016
- 卷：469
- 期：2
- 页码：281-287
- 全文大小：627 K
文摘
- •
α-MSH, at nM concentrations, protects osteoblasts from dexamethasone (Dex).
- •
Melanocortin receptor 4 (MC4R) acts as the receptor of α-MSH in osteoblasts.
- •
α-MSH activates sphingosine kinase 1 (SphK1), downstream on MC4R, in osteoblasts.
- •
SphK1 activation mediates α-MSH-exerted pro-survival effects in osteoblasts.