The increased amount of fatigue life of samples modified with optimum percentage (0.9% nano) compared to the control samples is between 15 and 35%. Using the bitumen modified with 0.9% Nano Fe2O3 in producing stone mastic asphalt mixtures can decrease the hot mix asphalt thickness. Results show that the increased rutting depth in all the modes is increasing with the usual rate. The amount of rut depth of asphalt samples containing 0.9% Nano Fe2O3 is about 25–40% lower than control samples.