Adenoviral Vector Vaccination Induces a Conserved Program of CD8+ T Cell Memory Differentiation in Mouse and Man
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- 作者：Beatrice Bolinger1 ; 7 ; 8 ; beatrice.bolinger@unibas.ch" class="auth_mail" title="E-mail the corresponding author ; Stuart Sims1 ; 8 ; Leo Swadling1 ; Geraldine O&rsquo ; Hara1 ; Catherine de Lara1 ; Dilair Baban2 ; Natasha Saghal2 ; Lian Ni Lee1 ; Emanuele Marchi1 ; Mark Davis3 ; Evan Newell4 ; Stefania Capone5 ; Antonella Folgori5 ; Ellie Barnes1 ; 6 ; Paul Klenerman1 ; 6
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：24 November 2015
- 年：2015
- 卷：13
- 期：8
- 页码：1578-1588
- 全文大小：4665 K
文摘
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Adenovector vaccination induces two transcriptionally distinct CD8 memory responses
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The sustained response induced by adenovectors and CMV is closely related
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The core molecular features are shared tightly in mouse and man
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Adenovaccines in humans induce a CD8 response that recapitulates these core features