The effect of hypoxia on cognitive performance in patients with chronic obstructive pulmonary disease

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• 作者：Susan E. Martin^a ; ^b ; ¹ ; ^{Susan.martin@belfasttrust.hscni.net"" rel=""nofollow} ; ^{ivanmartingi@nireland.com"" rel=""nofollow} ; Judy M. Bradley^a ; ^b ; ¹ ; ^{jm.bradley@ulster.ac.uk"" rel=""nofollow} ; Joseph B. Buick^b ; ^{Brian.Buick@belfasttrust.hscni.net"" rel=""nofollow} ; Amanda Crossan^b ; ^{Amanda.Crossan@bch.-n-i.nhs.uk"" rel=""nofollow} ; J. Stuart Elborn^b ; ^c ; ^{s.elborn@qub.ac.uk"" rel=""nofollow}
• 关键词：Cognitive function ; Hypoxia ; Hypoxic challenge testing
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2011
• 出版时间：30 June 2011
• 年：2011
• 卷：177
• 期：1
• 页码：36-40
• 全文大小：256 K

文摘

Air travel may cause significant hypoxia in passengers with chronic obstructive pulmonary disease (COPD). It is not known whether this level of hypoxia will cause impairment in cognitive function. The aim of this study was to determine the effect of hypoxia on cognitive performance in patients with COPD when Pa_O2 was decreased <6.6 kPa. In ten patients with moderate to severe COPD trail making tasks and complex figure tasks were used to assess cognitive performance when the patients breathed 21 % O₂, and when Pa_O2 was decreased to <6.6 kPa. During administration of 21 % O₂, Pa_O2 was 9.5 (8.9–10.2) kPa. When Sp_O2 was decreased to 85 % via manipulation of the FI_O2 (inspired fraction of oxygen) Pa_O2, decreased to 6.1 (5.9–6.2) kPa. No short term deterioration in visual search, mental flexibility or visuospatial constructional ability was detected when Pa_O2 was decreased to <6.6 kPa. The results show that short term exposure to hypoxia had no adverse effect on cognitive function.