Right-handed subjects (21-50 years), meeting DSM-IV criteria for MDD, either with (n = 19) or without (n = 20) childhood sexual or physical abuse. Healthy controls (n = 34) were matched for age, sex, education and smoking. 3D-MPRAGE images with a spatial resolution of 1.5 mm ¡Á 1.0 mm ¡Á 1.0 mm were acquired with a Siemens Sonata 1.5T system. Volumes of subgenual prefrontal cortex, amygdala and affective, cognitive, superior and posterior divisions of cingulate cortex were analyzed using DISPLAY software using reliable volumetric protocols. Groups were compared using ANCOVA, with intracranial volume as a covariate.
MDD subjects had low cingulate (cognitive division) and high amygdala volumes. Low cingulate volume was related to abuse and treatment history. Amygdala volume was predicted by subgenual prefrontal and cingulate (cognitive division) volumes and the presence of paracingulate cortex. Limitations: This study was cross sectional and the sample size was limited for subgroup and correlational analyses.
Our data suggest that MDD may be associated with alterations in anterior cingulate cortex and amygdala. Morphological variation, early stress and stress-protective factors may contribute to differences in fronto-limbic structures in MDD.