Design and synthesis of new potent PTP1B inhibitors with the skeleton of 2-substituted imino-3-substituted-5-heteroarylidene-1,3-thiazolidine-4-one: Part I
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- 作者：Ge Menga ; mengge@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Meilin Zhenga ; Mei Wanga ; Jing Tonga ; Weijuan Gea ; Jiehe Zhanga ; Aqun Zhengb ; Jingya Lic ; Lixin Gaoc ; Jia Lic ; jli@mail.shcnc.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：1 ; 3-Thiazolidine-4-one ; PTP1B ; Pyrrole ; Pyridine ; Dock ; SAR
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：21 October 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：756-769
- 全文大小：1550 K
文摘
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17 new compounds with two heterocycles were designed, synthesized as PTP1B inhibitor.
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All the molecules were tested for the inhibitory activities against PTP1B and CDC25B.
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Compound
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Compound
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Dock modes between