Substrate-gate coupling in ZnO-FET biosensor for cardiac troponin I detection

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• 作者：M.F.M. Fathil^a ; ^{faris.fathil@gmail.com}Author Vitae ; M.K. Md Arshad^a ; ^b ; ^{mohd.khairuddin@unimap.edu.my}Author Vitae ; A.R. Ruslinda^a ; ^{ruslinda@unimap.edu.my}Author Vitae ; Subash C.B. Gopinath^a ; ^c ; ^{subash@unimap.edu.my}Author Vitae ; M. Nuzaihan M.N.^a ; ^{m.nuzaihan@unimap.edu.my}Author Vitae ; R. Adzhri^a ; ^{adzhri@gmail.com}Author Vitae ; U. Hashim^a ; ^b ; ^{uda@unimap.edu.my}Author Vitae ; H.Y. Lam^d ; ^{drlamhy@yahoo.ca}
• 关键词：Biosensor ; Electrical-based ; Field-effect transistor ; Zinc oxide nanoparticles ; Substrate-gate coupling ; Cardiac troponin I
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：242
• 期：Complete
• 页码：1142-1154
• 全文大小：4113 K
• 卷排序：242

文摘

We presented a zinc oxide field-effect transistor biosensor. Substrate-gate coupling is introduced for enhancing current modulation. Immobilization of MAb-cTnI via covalent binding is highlighted. Electrical label-free detection of cardiac troponin I biomarker is demonstrated. The biosensor exhibited high sensitivity with limit of detection down to 3.24 pg/ml.