An avian influenza H5N1 virus vaccine candidate based on the extracellular domain produced in yeast system as subviral particles protects chickens from lethal challenge
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- 作者：Maria Pietrzaka ; 1 ; Agnieszka Maciołaa ; 1 ; Konrad Zdanowskia ; b ; Anna Maria Protas-Klukowskaa ; Monika Olszewskac ; Krzysztof Śmietankac ; Zenon Mintac ; Bogusław Szewczykd ; Edyta Koperaa ; ekopera@ibb.waw.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Avian influenza ; H5N1 ; Recombinant hemagglutinin ; Pichia pastoris
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：133
- 期：Complete
- 页码：242-249
- 全文大小：1859 K
文摘
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Recombinant H5 antigen based on the extracellular domain is able to induce strong immunological response.
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Deletion of the multibasic cleavage site in the H5 antigen improves protein oligomerization and its immunogenicity.
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Transmission electron microscopy visualized H5 subviral particles.
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This new antigen provides clinical protection following the challenge with HP H5N1 strain.