CC2D1A and CC2D1B regulate degradation and signaling of EGFR and TLR4
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- 作者：Rakesh Deshara ; Eun-Bee Chob ; Sungjoo Kim Yoona ; sjkyoon@catholic.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Jong-Bok Yoonb ; yoonj@yonsei.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CC2D1A ; CHMP4B ; Membrane receptor complex ; ESCRT ; Endosome
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：11 November 2016
- 年：2016
- 卷：480
- 期：2
- 页码：280-287
- 全文大小：2093 K
文摘
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CC2D1A binds to CHMP4B polymers formed on endosomes to regulate the endosomal sorting pathway.
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Depletion of CC2D1A and B accelerates EGFR down-regulation and termination of its downstream signaling through ERK1/2.
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Depletion of CC2D1A and B promotes sorting of EGFR to ILV.
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Depletion of CC2D1A and B enhances degradation of TLR4.