CC2D1A binds to CHMP4B polymers formed on endosomes to regulate the endosomal sorting pathway.
Depletion of CC2D1A and B accelerates EGFR down-regulation and termination of its downstream signaling through ERK1/2.
Depletion of CC2D1A and B promotes sorting of EGFR to ILV.
Depletion of CC2D1A and B enhances degradation of TLR4.