B cells present skewed profile and lose the function of supporting T cell inflammation after Roux-en-Y gastric bypass

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• 作者：Xiaojiang Dai^a ; ¹ ; Weiguo Zhao^a ; ¹ ; Junfang Zhan^b ; ¹ ; Songhua Zeng^c ; Dongzhi Ran^c ; Hongbin Zhang^c ; Zhigao Song^c ; Ken H. Song^d ; Liangping Wu^c ; ^{liangpingwu_gz@126.com}
• 关键词：B cell ; Diabetes ; Obesity ; RYGB
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：Complete
• 页码：16-22
• 全文大小：887 K
• 卷排序：43

文摘

We investigated the effect of RYGB on B cell inflammation. The regulatory to effector B cell ratio was increased after RYGB. B cells after RYGB lost the function of supporting T cell inflammation. IL-10 and TGF-β mediated the suppression by B cells after RYGB. Frequency of regulatory B cells correlated with reductions in obesity markers.