Mitochondrial STAT3 is negatively regulated by SOCS3 and upregulated after spinal cord injury
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- 作者：Keun Woo Parka ; 1 ; Ching-Yi Lina ; 1 ; Etty N. Benvenisteb ; Yu-Shang Leea ; leey2@ccf.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Suppressors of cytokine signaling-3 ; Short hairpin RNA ; Signal transducer and activator of transcription 3 ; Plasticity ; Spinal cord injury
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：284
- 期：part_PA
- 页码：98-105
- 全文大小：1305 K
文摘
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OSM differentially induces P-STAT3 Tyr and P-STAT3 Ser in SH-SY5Y cells.
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SOCS3 negatively regulated OSM-induced P-STAT3 Ser in mitochondria.
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SCI upregulates mitochondrial P-STAT3 Ser.
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SCI-induced P-STAT3 Ser is expressed by neurons and macrophages/microglia.