Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer
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- 作者：Robert Lesurf1 ; 2 ; 3 ; Miriam Ragle Aure4 ; 5 ; Hanne Hå ; berg Mø ; rk4 ; Valeria Vitelli6 ; Oslo Breast Cancer Research Consortium (OSBREAC) ; Torill Sauer ; Jü ; rgen Geisler ; Solveig Hofvind ; Elin Borgen ; Anne-Lise Bø ; rresen-Dale ; Olav Engebrå ; ten ; Ø ; ystein Fodstad ; Ø ; ystein Garred ; Gry Aarum Geitvik ; Rolf Kå ; resen ; Bjø ; rn Naume ; Gunhild Mari Mæ ; landsmo ; Hege G. Russnes ; Ellen Schlichting ; Therese Sø ; rlie ; Ole Christian Lingjæ ; rde ; Vessela Kristensen ; Kristine Kleivi Sahlberg ; Helle Kristine Skjerven ; Britt Fritzman
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 July 2016
- 年：2016
- 卷：16
- 期：4
- 页码：1166-1179
- 全文大小：6692 K
文摘
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Gene expression differences between DCIS and IDC are associated with intrinsic subtype
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Each subtype likely undergoes a distinct evolutionary course of disease progression
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Molecular properties that differentiate DCIS and IDC involve the microenvironment
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Subtype-specific signatures may have the potential to predict invasiveness