Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration
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- 作者：Daniel M. Vasconcelosa ; b ; c ; Raquel M. Gonç ; alvesa ; b ; 1 ; Catarina R. Almeidaa ; b ; i ; 1 ; Inê ; s O. Pereirab ; Marta I. Oliveirab ; d ; Nuno Nevesa ; b ; e ; Andreia M. Silvaa ; b ; c ; Antó ; nio C. Ribeirob ; Carla Cunhaa ; b ; Ana R. Almeidaa ; b ; c ; Cristina C. Ribeiroa ; b ; g ; Ana M. Gilh ; Elisabeth Seebachf ; Katharina L. Kynastf ; Wiltrud Richterf ; Meriem Lamgharia ; b ; Susana G. Santosa ; b ; susana.santos@ineb.up.pt" class="auth_mail" title="E-mail the corresponding author ; Má ; rio A. Barbosaa ; b ; c
- 关键词：Fibrinogen ; In vivo ; Bone repair/regeneration ; Inflammation ; Biomaterial
- 刊名：Biomaterials
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：163-178
- 全文大小：3725 K
文摘
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A pro-regenerative and immunomodulatory fibrinogen-based material is proposed.
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Fibrinogen scaffolds (Fg-3D) are biodegradable and induce a beneficial host response.
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The implantation of the fibrinogen scaffolds modulates the systemic immune response.
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Bone healing and homeostasis was promoted by fibrinogen scaffolds.