Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner
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- 作者：Lianjun Zhang1 ; lianjun.zhang@unil.ch" class="auth_mail" title="E-mail the corresponding author ; Benjamin O. Tschumi1 ; Isabel C. Lopez-Mejia2 ; Susanne G. Oberle3 ; Marten Meyer4 ; Guerric Samson1 ; Markus A. Rü ; egg5 ; Michael N. Hall5 ; Lluis Fajas2 ; Dietmar Zehn3 ; Jean-Pierre Mach6 ; Alena Donda1 ; Pedro Romero1 ; pedro.romero@unil.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Rictor ; mTORC2 ; Foxo1 ; CD8 T cell ; infection
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：9 February 2016
- 年：2016
- 卷：14
- 期：5
- 页码：1206-1217
- 全文大小：3951 K
文摘
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mTORC2 deficiency promotes MPEC generation and reduces SLECs during Listeria infection
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Primed mTORC2-deficient T cells have effector functions and produce higher IL-2 levels
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mTORC2-deficient memory CD8 T cells mount more potent recall responses
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mTORC2 deficiency promotes CD8 memory generation via nuclear accumulation of Foxo1