A Tell-Tail Sign of Chromatin: Histone Mutations Drive Pediatric Glioblastoma
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- 作者：Esther Rheinbay1 ; 2 ; 3 ; 4 ; David ; N. Louis2 ; Bradley ; E. Bernstein1 ; 2 ; 3 ; bernstein.bradley@mgh.harvard.edu ; Mario ; L. Suvà ; 1 ; 2 ; 3
- 刊名：Cancer Cell
- 出版年：2012
- 出版时间：20 March, 2012
- 年：2012
- 卷：21
- 期：3
- 页码：329-331
- 全文大小：813 K
文摘
Recent genomic analyses of pediatric glioblastoma, a poorly understood tumor with dismal outcome, have identified mutations in histone H3 variants that affect critical amino acids in the tail. The findings extend discoveries of chromatin regulator inactivation and gain-of-function mutations by documenting alteration of a modifiable histone residue in human cancer.