- 作者：Steffen Desch ; MD?/sup> ; stdesch@web.de ; Denis Schloma ; MD?/sup> ; Sven Mö ; bius-Winkler ; MD?/sup> ; Sandra Erbs ; MD?/sup> ; Stephan Gielen ; MD?/sup> ; Axel Linke ; MD?/sup> ; Jiangtao Yu ; MD&dagger ; ; Bernward Lauer ; MD&dagger ; ; Klaus Kleinertz ; MD&Dagger ; ; Wilfried Dä ; nschel ; MD&Dagger ; ; Gerhard Schuler ; MD?/sup> ; Holger Thiele ; MD?/sup>
- 关键词：diabetes mellitus ; late lumen loss ; paclitaxel ; sirolimus ; stents
- 刊名：JACC: Cardiovascular Interventions
- 出版年：2011
- 出版时间：April 2011
- 年：2011
- 卷：4
- 期：4
- 页码：452-459
- 全文大小：588 K
Objectives
The objective of the study was to assess noninferiority of the polymer-free sirolimus-eluting Yukon Choice stent (Translumina GmbH, Hechingen, Germany) compared with the polymer-based Taxus Libert¨¦ stent (Boston Scientific, Natick, Massachusetts) with regard to the primary endpoint, in-stent late lumen loss, at 9 months in patients with diabetes mellitus.Background
The Yukon Choice stent has been evaluated in several randomized controlled trials before, albeit to date, there has been no trial that exclusively enrolled patients with diabetes mellitus.
Methods
Patients with diabetes mellitus undergoing percutaneous coronary intervention for clinically significant de novo coronary artery stenosis were randomized 1:1 to receive either the polymer-free sirolimus-eluting Yukon Choice stent or the polymer-based paclitaxel-eluting Taxus Libert¨¦ stent.
Results
A total of 240 patients were randomized. Quantitative coronary angiography was available for 79 % of patients. Mean in-stent late lumen loss was 0.63 ¡À 0.62 mm for the Yukon Choice stent and 0.45 ¡À 0.60 mm for the Taxus Libert¨¦ stent. Based on the pre-specified margin, the Yukon Choice stent failed to show noninferiority for the primary endpoint. During follow-up, there were no significant differences between groups regarding death, myocardial infarction, stent thrombosis, target lesion revascularization, target vessel revascularization, or nontarget vessel revascularization.
Conclusions
Compared with the Taxus Libert¨¦ stent, the polymer-free sirolimus-eluting Yukon Choice stent failed to show noninferiority with regard to the primary endpoint, in-stent late lumen loss, in patients with diabetes mellitus after 9-month follow-up. Both stents showed comparable clinical efficacy and safety. (Yukon Choice Versus Taxus Libert¨¦ in Diabetes Mellitus; )